Vandana (Manju Warier) and Aby (Anoop Menon) are outstanding volleyball players and are a couple. Now a volleyball coach, Aby has started the most famous volleyball team named Karinkunnam Sixes. Due to an accident, Aby cannot play any more and this changes his life forever. His best players leave the team and join another team called Warriors, owned by Kuriachen. Upon seeing her husband so disheartened, Vandana sets off to fulfil his greatest wish.She arrives at the Central Jail as suggested by her close friend with the sole aim of putting together an efficient team of players. Hemalatha promised her that there are talented players in the jail and Vandana should just give them good coaching. Trained under Vandana, The Karinkunnam Sixes team including these new members get ready to participate in the Premiere League. The resulting intriguing events are plotted in Karinkunnam Sixes.